What is Lyophilization?
Lyophilization appliances are used in the production of freeze-dried drugs and foods.
Lyophilization; It is a process that combines the benefits of freezing and drying to obtain a dry, active, long shelf life and easily soluble product. It is a stabilization process in which the substance is first frozen, then sublimation and then desorption, in which the amount of solvent is reduced to values that do not support biological or chemical reactions.
Molecular and cell structure of the product is not damaged by lyophilization. It is dried and turned into medicine while preserving its nutritional values.
2. Primary drying (sublimation),
3. Secondary drying (desorption)
The product is subjected to freezing process. Depending on the product type, the duration of the freezing process may be longer or shorter. In the primary drying stage, a slight vacuum is applied in the lyophilization cabinet containing the product and as the temperature decreases gradually, high energy molecules fly out by themselves. In the secondary drying stage, the vacuum is maximized and the last water molecules crystallized and attached to the substance are pulled out of the material.
The product is freezed. Depending on the product type, the freezing process may be longer or shorter. In the primary drying stage, a light vacuum is applied in the lyophilization cabinet where the product is in and as the temperature decreases, the molecules of high energy fly out by themselves. In the secondary drying phase, the vacuum is maximized and the last water molecules that crystallize and hold onto the substance are pulled out of the material.
The Importance and Benefits of Lyophilization
Lyophilization devices are mainly used in the pharmaceutical and biotechnology industries. Freeze drying method is preferred in order to extend the shelf life of vaccines and other injectable products. By removing the water from the material and sealing the material in a vial, the material can be easily stored, shipped and then returned to its original form for injection.
Maintaining the stability and efficacy of drugs
Convenient and easy storage
To prevent aggregation and particle formation
To prevent chemical changes (such as hydrolysis) thanks to low humidity
Preventing oxidation with air
Smooth caked surface
Sterile production possibility
Minimum product damage
Easy to scale (scale-up)
Properties of High Quality Freeze-dried Materials:
Minimal activity loss (for example: proteins / pharmaceuticals, microorganisms)
Safe storage for a long time (not in contact with air)
Quick reconstitution (when water is added)
Advantages of Lyophilization
Vaccines and antibodies
Enzymes, hormones, and proteins
Erythocyte and serum
Viruses and bacteria
Other biological products
Some tissues are stored by lyophilization method for use in organ transplantation.
Active pharmaceutical ingredients
Pathological specimens and cultures
Proteins, enzymes, and hormones
Viruses and bacteria
Nutrasotics (Food Extract)
Aloe Vera, echinacea
Mussel and shark cartilage, algae
Seeds, tea and wheatgrass
For use in cheese, yoghurt, meat and probiotics.
Vaccines for pets
Bovine and poultry vaccines
Food produced for pets
Meat, fish and seafood
Fruit and juices
Astronaut food supplies
Proteins, enzymes for probiotics
Baby food proteins
Cheese, milk, yogurt, cream, ice cream
Rescuing valuable manuscript books and documents damaged by flood and fire
Preservation (taxidermy) of animal specimens exhibited in museums
Drying of flowers (taxidermy)